PGC-1α and Myokines in the Aging Muscle – A Mini-Review
نویسندگان
چکیده
منابع مشابه
PGC-1α and myokines in the aging muscle - a mini-review.
Aging is associated with far-reaching changes in physiological functions resulting in morbidity and ultimately death. Age-related frailty, insecurity and reduced physical activity contribute to a progressive loss of muscle mass and function, commonly referred to as sarcopenia. Due to the increase in life expectancy in many countries, loss of muscle mass and its consequences gain in relevance fo...
متن کاملSkeletal muscle as an endocrine organ: PGC-1α, myokines and exercise.
An active lifestyle is crucial to maintain health into old age; inversely, sedentariness has been linked to an elevated risk for many chronic diseases. The discovery of myokines, hormones produced by skeletal muscle tissue, suggests the possibility that these might be molecular mediators of the whole body effects of exercise originating from contracting muscle fibers. Even though less is known ...
متن کاملRole of PGC-1α in sarcopenia: etiology and potential intervention - a mini-review.
Sarcopenia is age-associated deterioration of muscle mass and function caused by a wide scope of physiological and pathological changes ranging from hormonal disorders to loss of subcellular homeostasis. Recent research indicates that mitochondrial dysregulation with advanced age plays a central role in the development of sarcopenia due to the multifactorial functions of this organelle in energ...
متن کاملTHE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC-1Α IN TYPE2 DIABETIC MALE RATS
Background: The purpose of this study was to compare the effects of a 12 weeks interval training with high and moderate intensity on PGC-1α of skeletal muscle in type 2 diabetic male rats. Methods: 40 male rats were divided into two groups: High fat diet (HFD) (n=32) and standard diet (C) (n=8) for 10 weeks. After inducing type2 diabetes via STZ, 8 diabetic rats (D) and 8 rats in group C rats ...
متن کاملMitochondria and PGC-1α in Aging and Age-Associated Diseases
Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders. Recent studies indicate that maintenance of mitochondr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gerontology
سال: 2011
ISSN: 1423-0003,0304-324X
DOI: 10.1159/000281883